学术报告（6月19日）

主持人:马杰

欢迎广大师生积极参与！

【摘要】主要介绍与蛋白质-DNA相互作用相关的生物物理以及两种基因组的调控机制。

【报告人简介】John F. Marko, MIT Ph.D. Departments of Molecular Biosciences and Physics & Astronomy Northwestern University Evanston, Illinois USA

Research Interest：

Our lab uses biophysical methods, with particular emphasis on micromanipulation of single DNA molecules and single chromosomes, to study the internal structure of chromosomes in vivo, and to study chromosome-organizing proteins and DNA topoisomerases in vitro. We also develop mathematical models relevant to these types of experiments. Projects in progress involve combining fluorescence microscopy and force microscopy in experiments on DNA-protein complexes and whole chromosomes, and in-vivo studies of coupling of chromosome dynamics to gene expression.